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An independent large study conducted by MEDCO Health Solutions Inc. found
that women treated with tamoxifen for breast cancer doubled the risk of the
disease returning if they used antidepressants--in particular, Paxil and
Prozac.



The researchers used medical records to identify 353 women taking tamoxifen
plus other drugs that might interfere with it, and 945 women taking
tamoxifen alone. Those taking a drug combo did so for about a year on
average.



Next, researchers checked to see how many were treated for second cancers in
the following two years. "Breast cancer recurred in about 7 percent of women
on tamoxifen alone, and in 14 percent of women also taking the
antidepressants Paxil and Prozac, and, to a lesser extent, Zoloft."



Medco's chief medical officer, Dr. Robert Epstein, said: If women want to
take an antidepressant, "you probably want to stay away from those three."



Source
Alliance For Human Research Protection


View drug information on Paxil CR; Prozac Weekly; Zoloft.